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TMZ reports Holmes is seeking full custody of the couple's one daughter, Suri.

By John Mitchell

Suri Cruise, Katie Holmes and Tom Cruise

Photo: James Devaney/ Getty Images

Tom Cruise has issued a statement responding to Katie Holmes' divorce filing Friday (June 29), saying he is "deeply saddened" by the end of their five-year marriage.

"Kate has filed for divorce and Tom is deeply saddened and is concentrating on his three children," his rep told People in a statement. "Please allow them their privacy to work this out."

News of the couple's separation broke earlier in the day when Holmes' attorney, Jonathan Wolfe, released a statement to People, saying, "This is a personal and private matter for Katie and her family. Katie's primary concern remains, as it always has been, her daughter's best interest." TMZ is reporting that Holmes is seeking full custody of the couple's daughter, Suri, in her divorce filing.

The pair wed at an Italian castle in 2006 in a lavish ceremony, attended by Jennifer Lopez and Marc Anthony, Will and Jada Pinkett Smith and Jim Carrey and Jenny McCarthy, after a whirlwind, very public and often controversial courtship that was perhaps best exemplified by Cruise's couch-jumping display during a now-infamous interview with Oprah Winfrey in 2005.

The pair have long been constantly at each other's side, but in recent weeks had uncharacteristically attended events solo. Cruise appeared without Holmes at the London and Hollywood premieres of his summer musical "Rock of Ages," while the actress was photographed in New York City with their daughter, Suri.

The marriage was Holmes' first and Cruise's third. The actor was previously married to actresses Nicole Kidman and Mimi Rogers.

• Tom Cruise And Katie Holmes: Five Years Of Romance

• Tom Cruise And Katie Holmes: In Happier Times